ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling
Abstract Type I interferon (IFN) signalling is tightly controlled.Upon Carpet recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling.Termination is achieved through autophagic degradation or recycling of STING by retrograde Go